Siamese cats are affectionate and intelligent cats, renowned for their social nature. Siamese cats enjoy being with people and are sometimes described as "extroverts". Siamese Cats are extremely vocal, with a loud, low-pitched voice - known as "Meezer", from which they get one of their nicknames - that has been compared to the cries of a human baby, and persistent in demanding attention. Siamese Cats also have a great need for human companionship. Often they bond strongly to a single person. Siamese cats are typically active and playful, even as adults.

The social orientation of Siamese cats may be related to their lessened ability to live independent of humans. Siamese cat coat colouration is appealing to humans, but is ineffective for camouflage purposes. Siamese Cats are less active at night than most cats, possibly because their blue eyes lack a tapetum lucidum, a structure which amplifies dim light in the eyes of other cats. Like blue-eyed white cats, Siamese Cats may also have reduced hearing ability, though most are not deaf. Indeed Siamese Cats are known for being an exception to the rule of thumb that white cats with blue eyes are deaf. Regardless, being dependent on humans may have been a survival trait for ancestors of the Siamese Cat.